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Faculty Profile

Sandra Shefelbine

222 ISEC
360 Huntington Avenue
Boston, MA 02115


  • PhD (2002), Mechanical Engineering, Stanford University

Research & Scholarship Interests

Multi-scale bone biomechanics – how the structure and composition of bone influences its mechanical properties; mechano-adaptation of bone and joint – how tissue responds to mechanical signals
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • 2011 Imperial College London Rector’s Medal of Excellence in Teaching
  • 2010 Royal Academy of Engineering Exxon Mobil Teaching Award
  • 2010 Faculty of Engineering Outstanding Teaching Award
  • 2010 Department of Bioengineering student selected ‘Best Teacher’ Award
  • 2005 RCUK Academic Fellowship
  • 2002 National Science Foundation International Research Fellowship

Teaching Interests

  • Solid mechanics
  • Dynamics
  • Musculoskeletal biomechanics

Selected Publications

  • B. Depalle, Z. Qin, S.J. Shefelbine, M.J. Buehler, Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content, Journal of Bone and Mineral Research, 31(2), 2016, 380-390
  • P. Yadav, S.J. Shefelbine, E.M. Gutierrez-Farewik, Effect of Growth Plate Geometry and Growth Direction on Prediction of Proximal Femoral Morphology, Journal of Biomechanics, 49(9), 2016, 1613-1619
  • M. Giorgi, A. Carriero, S.J. Shefelbine, N.C. Nowlan, Effects of Normal and Abnormal Loading Conditions on Morphogenesis of the Prenatal Hip Joint: Application to Hip Dysplasia, Journal of Biomechanics, 48(12), 2015, 3390-3397
  • B. Depalle, Z. Qin, S.J. Shefelbine, M.J. Buehler, Influence of Cross-Link Structure, Density and Mechanical Properties in the Mesoscale Deformation Mechanisms of Collagen Fibrils, Journal of the Mechanical Behavior of Biomedical Materials, 52, 2015, 1-13
  • B. Javaheri, A. Carriero, K.A. Staines, Y.-M. Chang, D.A. Houston, K.J. Oldknow, J.L. Millán, B.N. Kazeruni, P. Salmon, S.J. Shefelbine, C. Farquharson, A.A. Pitsillides, Phospho 1 Deficiency Transiently Modifies Bone Architecture yet Produces Consistent Modification in Osteocyte Differentiation and Vascular Porosity with Ageing, Bone, 81, 2015, 277-291
  • A.F. Pereira, B.  Javaheri, A.A. Pitsillides, S.J. Shefelbine, Predicting Cortical Bone Adaptation to Axial Loading in the Mouse Tibia, Journal of the Royal Society, Interface, 12(110), 2015
  • O.G. Andriotis, S.W. Chang, M. Vanleene, P.H. Howarth, D.E. Davies, S.J. Shefelbine, M.J. Buehler, P.J. Thurner, Structure-Mechanics Relationships of Collagen Fibrils in the Osteogenesis Imperfecta Mouse Model, Journal of the Royal Society, Interface/the Royal Society, 12(111), 2015
See Google Scholar Profile for all publications »

Related News

July 27, 2017

MIE/BioE Associate Professor Sandra Shefelbine awarded $650K NSF "Mechanobiology of Joint Morphogenesis: Manipulating Salamander Limbs" grant to study joint development by examining the regenerating limbs of salamanders.

February 1, 2017

BioE Assistant Professor Ambika Bajpayee (PI) and MIE/BioE Associate Professor Sandra Shefelbine (Collaborator) awarded a $310K DOD Peer Reviewed Medical Research Program Discovery Award

August 16, 2016

Using the injury of French gymnast Samir Ait Said during the Olympics, MIE associate professor Sandra Shefelbine explains how bones can break when different loads are placed on them.